"Cov kev ua tiav no feem ntau tau txais txiaj ntsig los ntawm kev tsim kho thev naus laus zis, kev tswj hwm tus qauv thiab kev tsim ntsuab."Zhang Ge tau hais tias, "Ua tsaug rau Deebio qhov kev siv zog tsis tu ncua rau qhov ua tau zoo, cov khoom lag luam bio-enzyme API muaj qhov zoo xws li kev ua haujlwm siab, siab huv thiab ruaj khov thiab yog li tau lees paub los ntawm cov neeg koom tes.

Ua Qhov Zoo Tshaj Plaws

Bio-enzymes yog cov proteins uas muaj cov haujlwm catalytic, uas txawv ntawm lwm cov proteins uas lawv muaj qhov chaw ua haujlwm.API ntawm bio-enzymes tau txais los ntawm kev sib cais, rho tawm thiab ua kom huv ntawm cov kab mob.

"Bio-enzyme API yog kev lag luam nrog kev nqis peev loj, cov txiaj ntsig qis thiab kev pheej hmoo siab.Kev lag luam nplai me me.Thiab muaj ob peb lub tuam txhab koom nrog nws. "Raws li Zhang Ge, qhov kev pheej hmoo siab yog vim kev ua haujlwm ntawm cov enzymes ua rau cov txheej txheem purification nyuaj dua.Piv txwv li, yog tias cov txheej txheem tswj tsis tau zoo, cov khoom yuav tsis muaj kev ua haujlwm, thiab tom qab ntawd poob nws cov nqi tshuaj.

Bio-enzyme API yog ib qho ntawm cov khoom siv raw ntawm bio-pharmaceuticals.Nrog rau cov tshuaj toxicity tsawg thiab cov kev mob tshwm sim, bio-pharmaceuticals yog tsom rau kev kho mob ntawm qee yam kab mob thiab yooj yim absorbed los ntawm tib neeg lub cev.Nws muaj qhov tshwj xeeb kho cov teebmeem rau ntshav qab zib, kab mob plawv, qog thiab kab mob kis.

"Kuv lub tswv yim zoo ib yam yog tias ntev npaum li kuv ua yam uas lwm tus tsis ua, kuv ua qhov zoo tshaj plaws."Zhang Ge ntseeg hais tias yog vim li cas nws tau ua hauv paus hauv kev lag luam bio-enzyme rau ntau tshaj 20 xyoo yog nws lub siab hlub rau enzymes.Nyob rau hauv 1990, tom qab kawm tiav ntawm Sichuan University (Lub qub Chengdu University of Science thiab Technology) loj nyob rau hauv biochemistry, Zhang Ge ua hauj lwm raws li ib tug kws thiab tom qab kuaj thawj coj nyob rau hauv Deyang Biochemical Pharmaceutical Factory.Tsib xyoos tom qab, vim lub Hoobkas rov tsim kho, nws tau tuav lub lag luam.

"Lub sijhawm ntawd, lub Hoobkas biochemical tab tom yuav hloov mus rau hauv lub tuam txhab tshuaj.Kuv mus rau ntawm lub Hoobkas mus xyuas thiab pom tias ob peb tug hluas tab tom kho lub rhiav me me qub.Lawv lub ntsej muag tau npog nrog dej thiab av nkos.Ntawm lawv yog Zhang Ge. "Zhong Guangde, yav tas los Tus Lwm Thawj Coj ntawm Sichuan Provincial Medical Administration Bureau, nco qab nrog kev xav, "Zhang Ge tseem yog tus tub hluas ua tej yam hauv kuv lub qhov muag."

Thaum lub Kaum Ob Hlis 1994, Zhang Ge nrhiav tau Sichuan Deyang Biochemical Products Co., Ltd. Thaum nws tau tsim, nws yuav luag poob.

"Thaum ntxov xyoo 1990, kev paub zoo ntawm Tuam Tshoj txoj kev lag luam Bio-enzyme feem ntau tsis muaj zog, thiab peb txoj kev nkag siab ntawm cov enzymes tseem txwv ntawm kev paub tias kev ua haujlwm enzyme zoo txaus."Raws li Zhang Ge, nyob rau lub Peb Hlis 1995, lub chaw tsim khoom tshiab Deyang Biochemical Products Co., Ltd. tau txais nws thawj qhov kev txiav txim rau cov roj crude kallidinogenase rau kev xa tawm mus rau Nyiv ua lag luam.Txawm li cas los xij, cov khoom raug tsis lees paub vim qhov sib txawv ntawm ob peb milligrams hauv cov ntsiab lus rog."Yog hais tias lwm tus neeg thov kom them nyiaj, lub tuam txhab yuav poob, thiab cov nyiaj them poob haujlwm yog hnub qub rau lub tuam txhab thaum lub sijhawm ntawd.Hmoov zoo, los ntawm kev sib koom tes, lwm tus neeg tsis tau hais kom peb them nyiaj tab sis cia peb rov muab cov khoom lag luam, "Zhang Ge hais.

Qhov kev paub no tau qhia Zhang Ge, uas nyuam qhuav pib ua lag luam, ib zaj lus qhia tseem ceeb thiab ua rau nws paub tias cov khoom lag luam zoo yog lub neej ntawm lub tuam txhab.Hauv 27 xyoo ntawm kev txhim kho hauv qab no, lub tuam txhab yeej ib txwm ua raws li cov qauv zoo.Raws li ntau xyoo ntawm kev tshawb fawb yooj yim, Deebio tau txhim kho nws cov thev naus laus zis tas li, yog li tsim kom muaj cov txheej txheem enzyme kev tiv thaiv tag nrho, kev ua kom tsis muaj kev puas tsuaj thiab cov cuab yeej ua kom huv huv kom ntseeg tau tias muaj kev ua haujlwm siab, siab purity thiab siab ruaj khov ntawm Bio-enzyme API cov khoom.

Sparing Tsis muaj zog los nqis peev hauv Innovation

"Kev lag luam bio-enzyme API yog qhov tshwj xeeb los ntawm qhov me me thiab muaj ntau haiv neeg.Yog tias tsis muaj kev tsim kho thev naus laus zis, ib lossis ob yam khoom tsis tuaj yeem txhawb nqa lub tuam txhab tsim.Deebio tsuas muaj ib yam khoom txij thaum nws tsim.Tab sis niaj hnub no muaj ntau tshaj li kaum ob bio-enzyme APIs, uas yog qhov sib cais tsis tu ncua ntawm peb cov peev txheej txuas ntxiv hauv thev naus laus zis. "Zhang Ge hais.

Trypsin-Chymotrypsin yog ib qho enzyme proteolytic sib cais thiab ua kom huv ntawm porcine pancreas.Nws yog ib qho ntawm Deebio cov khoom tseem ceeb.R & D ntawm cov khoom no tau txais txiaj ntsig los ntawm kev lag luam-tsev kawm ntawv-kev tshawb fawb kev koom tes.Xyoo 1963, Qi Zhengwu, tus kws tshawb fawb ntawm Shanghai Institute of Physiology thiab Biochemistry ntawm Suav Academy ntawm Kev Tshawb Fawb, tau siv recrystallization los rho tawm cov khoom siv sib xyaw ntawm chymotrypsin thiab trypsin los ntawm porcine pancreas, uas yog hu ua trypsin-chymotrypsin.Cov enzyme no tsis tau ua lag luam rau ntau tshaj 30 xyoo.Zhang Ge pom lub cib fim hauv nws."Hauv xyoo 1997, peb tau koom tes nrog pab pawg tshawb fawb ntawm kws tshawb fawb Qi Zhengwu kom paub txog kev lag luam ntawm trypsin-chymotrypsin thiab tau txais txiaj ntsig zoo ntawm kev lag luam thiab kev sib raug zoo.Thaum lub sijhawm zoo tshaj plaws, ntau tshaj 20 tons hauv ib xyoos ntawm cov khoom no raug xa tawm mus rau Is Nrias teb. "Raws li Zhang Ge, kws tshaj lij Qi Zhengwu tau hais tias "Zoo kawg, kuv cov khoom tau raug tsim los ntawm nroog thiab cov tuam txhab hauv zos.

Tom qab saj qhov qab zib ntawm kev tsim kho thev naus laus zis, Deebio tau ntxiv nws cov peev txheej hauv kev siv thev naus laus zis, thiab tsim kev sib raug zoo ntawm kev lag luam-tsev kawm ntawv-kev tshawb fawb kev koom tes nrog Tsinghua University, Suav Academy ntawm Sciences, Sichuan University, Tuam Tshoj Pharmaceutical University thiab lwm lub tsev kawm ntawv qib siab thiab kev tshawb fawb institutes. , los tsim cov chaw soj nstuam, txuas ntxiv txhim kho pab pawg kev tshawb fawb thiab kev tsim kho tshiab muaj peev xwm thiab tsim kom muaj kev tsim khoom thiab R & D pab pawg nrog cov cuab yeej hloov pauv siab uas tau ua tiav tau txais 15 patented technologies.

Txhawm rau txhim kho cov khoom lag luam zoo, hauv 2003, Deebio tau koom tes nrog German tus khub nrog kev siv thev naus laus zis ntau dua thiab kev tswj hwm muaj peev xwm tsim kom muaj kev sib koom tes hu ua Deyang Sinozyme Pharmaceutical Co., Ltd. "Nyob rau xyoo ntawd, peb tau nqis peev ntau dua 20 lab yuan. los tsim cov nroj tsuag tshiab, nrog rau cov khoom siv ntau lawm ua nrog cov khoom siv hauv ntiaj teb sab saum toj.Nyob rau tib lub sijhawm, lub Hoobkas tuaj yeem tsim hauv Suav teb rau 5 lab yuan.Tus nqi ntawm kev tsim Sinozyme yog sib npaug ntawm 4 lub chaw tsim khoom. "Raws li Zhang Ge, tus khub German tau mus xyuas lub tuam txhab los qhia txog kaum hnub txhua lub hlis.Nrog rau kev qhia txog cov txheej txheem kev tswj hwm kev ua tau zoo, Sinozyme lub peev xwm tswj tau zoo tau raug tsa mus rau qib siab thoob ntiaj teb.

Xyoo 2005, Sinozyme tau los ua thawj lub tuam txhab suav pancreatin kom tau txais daim ntawv pov thawj EU-GMP;nyob rau hauv 2011, Sichuan Deebio Pharmaceutical Co., Ltd. tau tsim;Xyoo 2012, Deebio tau txais ntawv pov thawj CN-GMP;Nyob rau lub Ib Hlis 2021, Deebio (Chengdu) Bio-technology Co., Ltd. tau tsim los rau R&D, tsim khoom thiab siv cov tshuaj tiav high-end thiab biotechnology enzyme npaj.

"Kuv xav tias cov tuam txhab lag luam yuav tsum txaus siab los nqis peev hauv kev tsim cov thev naus laus zis tshiab.Deebio tau tsim lub Hoobkas tshiab txhua txhua 7 txog 8 xyoo.Hauv cov xyoo no, feem ntau ntawm cov txiaj ntsig tau nqis peev hauv kev tsim kho kev lag luam, kev hloov khoom siv ntau lawm thiab kev qhia txuj ci.Cov tswv cuab thiab cov thawj coj tau txais ob peb cov nyiaj faib. "Zhang Ge, ib zaug ib tug engineer, nkag siab txog qhov tseem ceeb ntawm kev lag luam thev naus laus zis.Nws khaws cov kev hloov pauv tshiab, thiab tau teev cov khoom yuav tsum tau ua: Deebio qhov kev cob qhia tshiab GMP ua raws li FDA cov qauv tau pib xyoo tas los thiab xav tias yuav ua tiav thaum lub Tsib Hlis lig thiab nkag mus rau kev sim tsim khoom;Deebio (Chengdu) Bio-technology Co., Ltd., nyob hauv Wenjiang, Chengdu, tau pib tsim kho thaum lub Plaub Hlis 26 thiab xav tias yuav raug muab tso rau hauv lub Kaum Hli.

"Green Production yog qhov kuv txaus siab tshaj plaws"

Cov pa phem ntawm API yeej ib txwm muaj kev txhawj xeeb ntawm tib neeg, thiab kev tiv thaiv ib puag ncig tau dhau los ua qhov muaj kev ntxhov siab uas txiav txim siab txog kev ciaj sia ntawm kev lag luam.Ua raws li kev tsim ntsuab yog qhov uas Zhang Ge txaus siab tshaj plaws.

"Thaum pib tsim lub tuam txhab, peb tsis tau them nyiaj ntau rau cov teeb meem ib puag ncig.Tab sis tom qab ntawd, raws li lub teb chaws tau tso tseg kev tiv thaiv ib puag ncig, peb tau pib paub txog nws qhov tseem ceeb. "Raws li Zhang Ge, nyob rau hauv kaum xyoo dhau los, Deebio tau them nyiaj ntau rau nws, siv zog ua kom muaj kev loj hlob ruaj khov.

Nws yog ib qho xwm txheej uas ua rau muaj kev hloov pauv."Ntawm lub rooj sib tham ntau xyoo dhau los, peb lub tuam txhab cov thawj coj tau npaj rau cov khoom lag luam uas xav tau qee cov tshuaj reagents.Ib qho ntawm cov tshuaj reagents tsis tuaj yeem degraded thiab, yog tias cov dej khib nyiab tau tso rau hauv tus dej, nws yuav ua rau me nyuam deformities.Kuv tsis muaj peev xwm hais tsis tau rau cov khoom no. "Hais txog qhov xwm txheej, Zhang Ge tau zoo siab heev, "Kuv lub nroog nyob ntawm tus dej Tuojiang, uas nyob deb tshaj 200 mais deb ntawm Guanghan, Sichuan.Thiab tus dej ntawm peb lub Hoobkas ntws mus rau hauv tus dej Tuojiang.Kev tso dej tawm ncaj qha yog kev ua txhaum cai rau cov tiam tom ntej.Yog li kuv yuav tsis ua li ntawd. "

Txij thaum ntawd los, Deebio tau teev tseg tias ntev npaum li cov txheej txheem tsim khoom muaj cov khoom siv tshuaj lom thiab phom sij lossis cov khoom siv pabcuam uas tsis tuaj yeem ua tiav hauv kev tsim cov khoom tshiab, kev loj hlob yuav tsum tsis pub, thiab nws tau hais rau kev nqis peev hauv kev tiv thaiv ib puag ncig rau. tshaj kaum xyoo.

Niaj hnub no, Deebio tau tsim lub vaj-style chaw kho dej khib nyiab nrog kev kho txhua hnub ntawm 1,000m³, nrog cov dej khib nyiab tawm tom qab ncav cuag tus qauv.“Lub peev xwm no txaus rau peb siv tau kaum xyoo.Thiab ib lub vaj tau tsim tshwj xeeb tshaj qhov chaw kho dej khib nyiab.Cov dej kho tau tuaj yeem siv los tsa ntses thiab dej paj, "Zhang Ge hais tias khav theeb.

Tsis tas li ntawd, cov roj khib nyiab tuaj yeem kho tau los ntawm kev txau thiab lwm txoj hauv kev, thiab cov roj biogas tuaj yeem siv los ua kom sov lub boiler tom qab degassing thiab lub cev qhuav dej, yog li txuag tau 800m³ roj av txhua hnub.Rau cov khib nyiab tsim, muaj kev cob qhia tshwj xeeb ua haujlwm.Cov pov tseg cov protein tau hloov mus rau hauv cov chiv ua chiv tsis pub dhau 4 feeb los ntawm lub tshuab ziab khaub ncaws thiab xa mus rau cov nroj tsuag chiv.

Zhang Ge tau hais txog kev xav, "Tam sim no tag nrho thaj chaw cog tsis tsim cov ntxhiab tsw tshwj xeeb, thiab cov dej khib nyiab thiab cov pa phem raug tswj xyuas kom zoo.Kuv txaus siab rau qhov no dua li kev tsim cov khoom lag luam, uas yog qhov ua tiav kuv muaj nuj nqis tshaj plaws. "

Hais txog kev txhim kho yav tom ntej, Zhang Ge muaj kev ntseeg siab, "Txoj kev loj hlob ntawm kev lag luam yuav tsum muaj kev vam meej.Txoj kev loj hlob zoo ntawm bio-enzyme API kev lag luam txhais tau tias tsis yog tsuas yog kev tsim cov khoom lag luam zoo xwb, tab sis kuj tseem muaj cov cuab yeej siv siab dua, kev ua haujlwm zoo dua, kev tswj hwm ntau dua, thiab ntau txoj kev tsim khoom zoo ib puag ncig.Deebio yuav ua tus thawj coj ntawm kev lag luam kev loj hlob zoo raws li nws lub luag haujlwm, thiab ua siab dawb pab txhua tus tib neeg rau lawv txoj kev noj qab haus huv raws txoj hauv kev ntawm txoj kev loj hlob tshiab. "